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Updated: Jul 18, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Solid-state characterization of two polymorphic forms of R-albuterol sulfate
M A Palacio1, S Cuffini, R Badini
1Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa María de Punilla 5164, Córdoba, Argentina.
Abstract:
R-albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray powder diffraction, FT-IR spectroscopy, visual and microscopic inspection, and DSC. Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II.
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