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Ghost cell odontogenic carcinoma.

S P Nazaretian1, M E Schenberg, I Simpson

  • 1Department of Anatomical Pathology, Southern Cross Pathology, Southern Health, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia. simon.nazaretian@med.monash.edu.au <simon.nazaretian@med.monash.edu.au>

International Journal of Oral and Maxillofacial Surgery
|December 5, 2006
PubMed
Summary
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Ghost cell odontogenic carcinoma (GCOC) is a rare malignant tumor. This case report details a middle-aged male with a maxillary GCOC, highlighting the need for more research on this aggressive odontogenic neoplasm.

Area of Science:

  • Oral and Maxillofacial Pathology
  • Odontogenic Tumors
  • Neoplasia

Background:

  • Ghost cell odontogenic carcinoma (GCOC) represents the malignant progression of calcifying cystic odontogenic tumors and dentinogenic ghost cell tumors.
  • Odontogenic carcinomas are rare malignant neoplasms originating from odontogenic epithelium.

Observation:

  • A middle-aged male presented with a slowly enlarging maxillary tumor.
  • The patient was initially asymptomatic, but developed pain preceding the clinical presentation.
  • Surgical excision revealed a tumor consistent with GCOC.

Findings:

  • Histopathological diagnosis confirmed ghost cell odontogenic carcinoma.
  • The tumor exhibited characteristic ghost cells within the neoplastic odontogenic epithelium.

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Implications:

  • This case underscores the clinical presentation and diagnosis of GCOC.
  • Further case reports are crucial for a comprehensive understanding of GCOC's behavior and treatment.
  • Increased awareness and reporting are vital for advancing research on this rare malignant odontogenic tumor.