Related Experiment Video
Updated: Jul 18, 2026

Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
Published on: September 13, 2020
Characterization of synthesized titanium oxide nanoclusters by MALDI-TOF mass spectrometry
Bing Guan1, Weigang Lu, Jiye Fang
1Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
Abstract:
Titania represents an important material that has wide applications. The bactericidal efficiency of TiO(2) has been shown to be dependent on the size of the nanoparticles, so it is important to be able to reliably estimate their dimensions. In this study, a stable TiO(2) cluster suspension is produced by the thermal solvent process, and ultrasmall clusters (<1 nm) with different sizes are obtained by size-selection treatment. MALDI-TOF-MS and LDI-TOF-MS are shown to be useful for characterization of these ultrasmall nanoparticles. Peak maxima are found to correlate with nanoparticle size, and the possibility of using these mass spectrometry-based approaches to estimate nanoparticle size is affirmed. The size distributions of TiO(2) nanoparticles obtained from MALDI- and LDI-TOF-MS are in good agreement with parallel TEM observations. Finally, PSD analysis of inorganic nanomaterials is performed and valuable information about the structure of analytes has been obtained.
More Related Videos
06:56Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
07:54Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials
Published on: October 27, 2020
Related Concept Videos
MALDI-TOF Mass Spectrometry
Tandem Mass Spectrometry
Peptide Identification Using Tandem Mass Spectrometry
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...