Related Experiment Video
Updated: Jul 18, 2026
06:38
Pattern-based Search of Epigenomic Data Using GeNemo
Published on: October 8, 2017
Genomes: epigenomics and the future of genome sciences
1Department of Biological Sciences, Smith College, Northampton, Massachusetts 01063, USA. Lkatz@smith.edu
Current Biology : CB
|December 5, 2006
Summary
Epigenomics is a rapidly advancing field. The newly sequenced Tetrahymena thermophila genome will significantly enhance our understanding of genome-wide epigenetic implications.
Area of Science:
- Genomics
- Epigenetics
- Molecular Biology
Background:
- Epigenetics studies heritable changes in gene expression without altering the underlying DNA sequence.
- Understanding the genome-wide implications of epigenetics is still in its early stages across diverse organisms.
- Epigenomics integrates genomics with epigenetics to explore these regulatory mechanisms.
Purpose of the Study:
- To highlight the significance of the Tetrahymena thermophila macronuclear genome sequence.
- To underscore the potential of this genomic resource for advancing the field of epigenomics.
Main Methods:
- Genome sequencing of Tetrahymena thermophila.
- Bioinformatic analysis of the sequenced genome.
Main Results:
- The completion of the Tetrahymena thermophila macronuclear genome sequence provides a foundational resource.
- This resource is poised to facilitate comprehensive epigenomic studies.
Conclusions:
- The Tetrahymena thermophila genome sequence represents a critical step forward for epigenomics.
- Further research utilizing this genome will deepen our understanding of genome-wide epigenetic regulation.
Related Concept Videos
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:29Pharmacogenetics and Pharmacogenomics: Overview
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...