Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed L-DOPA-induced hyperalgesia.

T Shimizu1, S Iwata, A Miyata

  • 1Department of Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan.

Pharmacology, Biochemistry, and Behavior
|December 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling new quantum phases in the Shastry-Sutherland compound SrCu<sub>2</sub>(BO<sub>3</sub>)<sub>2</sub> up to the saturation magnetic field.

Nature communications·2023
Same author

Ultrasound measurement technique for the single-turn-coil magnets.

The Review of scientific instruments·2021
Same author

Communication with Peritoneal Dialysis Patients Post-Kumamoto Earthquake.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2017
Same author

Liver stiffness measurement using acoustic radiation force impulse elastography in hepatitis C virus-infected patients with a sustained virological response.

Alimentary pharmacology & therapeutics·2016
Same author

Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats.

Free radical research·2014
Same author

Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factors.

European journal of pharmacology·2012
Same journal

Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

Pharmacology, biochemistry, and behavior·2026
Same journal

Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

Pharmacology, biochemistry, and behavior·2026
Same journal

Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

Pharmacology, biochemistry, and behavior·2026
Same journal

Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

Pharmacology, biochemistry, and behavior·2026
Same journal

Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

Pharmacology, biochemistry, and behavior·2026
Same journal

Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

Pharmacology, biochemistry, and behavior·2026
See all related articles

Levodopa (L-DOPA) can cause hyperalgesia, or increased pain sensitivity, by converting to dopamine. This effect involves both D1 and D2 dopamine receptors, suggesting temporary impairment of the pain-inhibitory system.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Levodopa (L-DOPA) exhibits antinociceptive effects but can also induce hyperalgesia.
  • The mechanism behind L-DOPA-induced hyperalgesia requires further investigation.

Purpose of the Study:

  • To elucidate the mechanism underlying L-DOPA-induced hyperalgesia.
  • To determine the role of dopamine conversion and specific dopamine receptors in this phenomenon.

Main Methods:

  • Administration of L-DOPA and co-administration with benserazide (DOPA decarboxylase inhibitor) in mice.
  • Utilized D2 receptor agonist (quinpirole), D1 antagonist (SCH23390), and D2 antagonist (sulpiride).
  • Measured nociceptive behaviors and spinal cord dopamine levels.

Related Experiment Videos

Main Results:

  • L-DOPA administration enhanced nociceptive behaviors 2 hours post-administration.
  • Benserazide abolished L-DOPA-induced hyperalgesia, indicating dopamine conversion is critical.
  • D1 and D2 receptors are implicated, with D1 antagonism inhibiting hyperalgesia and D2 antagonism showing no effect on L-DOPA-induced hyperalgesia.
  • Spinal cord dopamine levels surged post-L-DOPA and returned to baseline within 1 hour.

Conclusions:

  • L-DOPA-induced hyperalgesia results from dopamine conversion and subsequent interaction with D1 and D2 receptors.
  • Excess exogenous dopamine from L-DOPA may temporarily impair the spinal dopaminergic pain-inhibitory system.
  • Both D1 and D2 receptors play a role in the hyperalgesic response to L-DOPA.