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Subacute necrotizing sialadenitis: a clinicopathological study.

Lakshmanan Suresh1, Alfredo Aguirre

  • 1Advanced Oral and Maxillofacial Pathology Program, School of Dental Medicine, State University of New York at Buffalo, NY 14214, USA.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|December 5, 2006
PubMed
Summary

Subacute necrotizing sialadenitis (SANS) is an uncommon inflammatory condition affecting minor salivary glands. This self-limiting condition presents with distinct clinical and histological features, potentially related to necrotizing sialometaplasia.

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Area of Science:

  • Oral Pathology
  • Salivary Gland Diseases
  • Inflammatory Conditions

Background:

  • Subacute necrotizing sialadenitis (SANS) is an uncommon inflammatory condition.
  • It typically affects minor salivary glands, particularly those in the palate.
  • The etiopathogenesis, clinical presentation, and histology of extra-palatal SANS require further characterization.

Purpose of the Study:

  • To report and characterize cases of extra-palatal subacute necrotizing sialadenitis (SANS).
  • To describe the etiopathogenesis, clinical features, and histology of SANS.
  • To differentiate SANS from similar conditions like necrotizing sialometaplasia (NS).

Main Methods:

  • Retrospective review of patient records with SANS diagnoses between 1999 and 2005.

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  • Inclusion criteria: complete clinical history and histological data.
  • Analysis of clinical presentation, lesion characteristics, and histological findings.

    • Main Results:

    • Five cases of extra-palatal SANS were identified (3 women, 2 men).
    • Patients presented with painful, rapidly enlarging swellings (1.0-1.5 cm) on the buccal mucosa, tongue, or lip.
    • Histology revealed acinar necrosis with inflammatory infiltrate and eosinophilia; lesions healed spontaneously within 3 weeks without recurrence.

    Conclusions:

    • SANS is an uncommon, self-limiting inflammatory condition of minor salivary glands with distinct clinical and histological features.
    • Histological similarities between SANS and early necrotizing sialometaplasia (NS) suggest a potential relationship.
    • Further case reporting is essential for better defining SANS and distinguishing it from NS.