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euHCVdb: the European hepatitis C virus database.

Christophe Combet1, Nicolas Garnier, Céline Charavay

  • 1Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1, IFR 128 BioSciences, Lyon-Gerland, France. c.combet@ibcp.fr

Nucleic Acids Research
|December 5, 2006
PubMed
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This summary is machine-generated.

The European Hepatitis C Virus Database (euHCVdb) offers a valuable resource for studying hepatitis C virus (HCV) genetic variability. This database aids research in molecular virology, pathogenesis, drug design, and vaccine development.

Area of Science:

  • Virology
  • Bioinformatics
  • Structural Biology

Background:

  • Hepatitis C virus (HCV) exhibits significant genetic variability, complicating research and therapeutic development.
  • A centralized, annotated database is crucial for understanding HCV diversity and advancing scientific study.

Purpose of the Study:

  • To introduce the European Hepatitis C Virus Database (euHCVdb) as a comprehensive resource for HCV sequence and structural data.
  • To facilitate research in HCV molecular virology, pathogenesis, drug design, and vaccine development.

Main Methods:

  • Development of a computer-annotated sequence database based on reference genomes.
  • Inclusion of genome mapping, nomenclature, subtyping, and 3D molecular models.
  • Creation of a WWW interface for data searching and export.

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Main Results:

  • The euHCVdb provides access to a curated collection of HCV sequences and associated annotations.
  • The database supports sequence and structure analyses through its user-friendly interface.
  • euHCVdb is part of an international collaboration, focusing on HCV protein sequences, 3D structures, and functional analyses.

Conclusions:

  • The euHCVdb is an essential tool for researchers investigating HCV genetic and structural variability.
  • The database enhances studies on HCV pathogenesis, drug design, and vaccine development.
  • euHCVdb promotes international collaboration in hepatitis C research.