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PATRIC: the VBI PathoSystems Resource Integration Center.

E E Snyder1, N Kampanya, J Lu

  • 1Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. eesnyder@vbi.vt.edu

Nucleic Acids Research
|December 5, 2006
PubMed
Summary

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This summary is machine-generated.

The PathoSystems Resource Integration Center (PATRIC) offers a comprehensive bioinformatics resource for NIAID priority pathogens. This resource integrates genome, proteome, and metabolic data to accelerate the development of drugs, vaccines, and diagnostics.

Area of Science:

  • Bioinformatics
  • Infectious Disease Research
  • Genomics

Background:

  • The National Institute of Allergy and Infectious Diseases (NIAID) funds eight Bioinformatics Resource Centers (BRCs).
  • PATRIC is one such BRC, focusing on NIAID priority pathogens.

Purpose of the Study:

  • To establish a centralized data and analysis resource for specific NIAID priority pathogens.
  • To facilitate research and development of countermeasures, including drugs, vaccines, and diagnostics.

Main Methods:

  • Implementing a three-pronged curation strategy: 'breadth first', 'targeted', and 'integrative'.
  • Utilizing standardized protocols for whole-genome and proteome curation.
  • Leveraging high-throughput experimental data and literature for data integration.

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Main Results:

  • Warehousing complete genome sequences for 17 bacterial and 332 viral species.
  • Developing a relational database, analytical pipelines, and a user-friendly website.
  • Providing capabilities for data browsing, querying, visualization, and download.

Conclusions:

  • PATRIC serves as a vital, growing resource for NIAID priority pathogen research.
  • The integrated data and analysis tools aim to accelerate countermeasure development.
  • The platform supports diverse research needs through comprehensive data and functionality.