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Occult herpesvirus folliculitis clinically simulating pseudolymphoma
1Department of Pathology and Medicine, M.S. Hershey Medical Center, Pennsylvania State University.
The American Journal of Dermatopathology
|June 1, 1991
Summary
Cutaneous herpesvirus infections can mimic pseudolymphoma. Recognizing characteristic histologic features of herpesvirus folliculitis is key for accurate diagnosis in unsuspected cases.
Area of Science:
- Dermatopathology
- Virology
- Histopathology
Background:
- Cutaneous infections caused by herpesviruses can present with varied clinical manifestations.
- Distinguishing viral infections from other dermatological conditions like pseudolymphoma is crucial for appropriate patient management.
Observation:
- Two cases of cutaneous herpesvirus infection clinically resembled pseudolymphoma.
- Histological examination revealed viral changes in pilosebaceous units, with surface epithelium spared.
- Dermal findings included dense perivascular and perifollicular inflammation, with multinucleated lymphoid cells in one case and viral inclusions in fibroblasts in the other.
Findings:
- Immunoperoxidase stains for herpes simplex virus types I and II were positive in one case and negative in the other.
- Ultrastructural analysis confirmed the presence of herpesvirus particles in both cases.
- Characteristic histologic features of herpesvirus folliculitis were identified.
Implications:
- Accurate diagnosis of cutaneous herpesvirus infection relies on recognizing specific histologic patterns.
- Histologic evaluation is essential for differentiating herpesvirus folliculitis from pseudolymphoma.
- Early and accurate diagnosis facilitates timely and effective treatment of herpesvirus infections.