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Covered retrievable prostatic urethral stents: feasibility study in a canine model
Chang Jin Yoon1, Ho-Young Song, Ji Hoon Shin
1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-2dong, Songpa-gu, Seoul, Republic of Korea.
Journal of Vascular and Interventional Radiology : JVIR
|December 5, 2006
Summary
Covered, retrievable prostatic urethral stents are feasible in dogs. Stent-induced urethral dilation and prostate atrophy persisted for 8 weeks post-removal, with reduced hyperplasia and inflammation over time.
Area of Science:
- Urology
- Veterinary Medicine
- Biomedical Engineering
Background:
- Prostatic urethral stents are used to treat benign prostatic hyperplasia.
- Covered, retrievable stents offer potential advantages for managing prostatic urethra conditions.
Purpose of the Study:
- To assess the feasibility of using covered, retrievable prostatic urethral stents in a canine model.
- To evaluate urethrographic and histologic changes in the prostate following stent placement and removal.
Main Methods:
- Polytetrafluoroethylene-covered nitinol stents were implanted in 13 dogs for 8 weeks.
- Urethrograms were performed bi-weekly; histologic analysis compared prostates post-removal (immediate vs. 8 weeks).
Main Results:
- Stent placement and removal were technically successful in most dogs.
- Prostatic urethral dilation persisted post-removal; glandular atrophy and fibrosis were noted.
- Mucosal hyperplasia and inflammation decreased significantly by 8 weeks after stent removal.
Conclusions:
- Covered, retrievable prostatic urethral stents appear feasible for canine use.
- Stent-induced prostatic urethral dilation and glandular atrophy are persistent findings up to 8 weeks post-removal.
