Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modelling radiation-induced bystander effect and cellular communication.

F Ballarini1, D Alloni, A Facoetti

  • 1Dipartimento di Fisica Nucleare e Teorica, Università degli Studi di Pavia, via Bassi 6, 27100 Pavia, Italy. francesca.ballarini@pv.infn.it

Radiation Protection Dosimetry
|December 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incorporation of dose-rate effects into the BIANCA biophysical model and application for space radiation risk assessment.

Life sciences in space research·2026
Same author

Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem‑ion): Interim report of a randomized phase II pilot trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Activation of the visual system by space radiation: A novel study on Ca<sup>2+</sup> signalling in ex-vivo rabbit eyes exposed to visible light, X-rays and high-energy protons.

Life sciences in space research·2025
Same author

Enhancing human islet xenotransplant survival and function in diabetic immunocompetent mice through LRH-1/NR5A2 pharmacological activation.

Frontiers in immunology·2024
Same author

A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events.

Life sciences in space research·2024
Same author

Biological effectiveness of He-3 and He-4 ion beams for cancer hadrontherapy: a study based on the BIANCA biophysical model.

Physics in medicine and biology·2021

Radiation exposure can harm cells that were not directly hit, known as bystander effects. This study explores the mechanisms and modeling of these non-targeted effects to better understand radiation risks.

Area of Science:

  • Radiobiology
  • Radiation Protection
  • Cellular Communication

Background:

  • Accumulating evidence over the last decade highlights radiation-induced non-targeted effects, particularly bystander effects.
  • Bystander effects involve damage induction in non-irradiated cells, likely mediated by soluble factors released from irradiated cells.
  • These effects have been observed for various lethal and non-lethal biological endpoints.

Purpose of the Study:

  • To investigate the mechanisms underlying radiation-induced non-targeted effects.
  • To explore the role of cellular communication (gap junctions, extracellular messengers) in these phenomena.
  • To present and analyze theoretical models for understanding non-targeted damage and low-dose radiation risk.

Main Methods:

  • Review and detailed presentation of three theoretical models, including one from the University of Pavia.

Related Experiment Videos

  • Analysis of model assumptions and their implications for non-targeted radiobiological damage.
  • Comparison of model predictions with experimental data.

    • Main Results:

    • Cellular communication mechanisms, including gap junctions and extracellular messengers, play a pivotal role in non-targeted effects.
    • Modulation of these effects by factors like cell type, cell cycle, density, and time post-irradiation is significant.
    • Theoretical models offer insights into the mechanisms and potential deviations from linear dose-risk relationships in radiation protection.

    Conclusions:

    • Understanding non-targeted effects is crucial for accurate radiation risk assessment, especially at low doses.
    • Theoretical modeling is a valuable tool for elucidating the complex mechanisms of bystander effects.
    • Further research and model development are needed to refine radiation protection strategies based on non-targeted phenomena.