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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

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Related Experiment Video

Updated: Jul 18, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Leukemic stem cells: where do they come from?

Emmanuelle Passegué1, Irving L Weisman

  • 1Stanford University School of Medicine, Pathology Department, Beckman Center B259, Stanford, CA 94305, USA. passegue@stanford.edu

Stem Cell Reviews
|December 5, 2006
PubMed
Summary

Leukemic stem cells (LSCs) drive leukemia by uncontrolled proliferation. Mouse models reveal LSCs can originate from both stem cells and progenitors, depending on oncogenic events.

Area of Science:

  • Hematology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Leukemias are driven by rare cancer stem cells (leukemic stem cells, LSCs).
  • LSCs possess indefinite proliferation capacity due to mutations or epigenetic changes.
  • The developmental origin and emergence mechanisms of LSCs require further investigation.

Purpose of the Study:

  • To investigate the developmental origins of leukemic stem cells (LSCs).
  • To understand the mechanisms governing LSC generation and function.
  • To explore how oncogenic events influence LSC identity and behavior.

Main Methods:

  • Utilized mouse models of human leukemias.
  • Studied mechanisms influencing LSC generation and function.
  • Analyzed LSC origins from hematopoietic stem cells (HSCs) and progenitor populations.

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

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Published on: March 26, 2018

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Main Results:

  • Demonstrated that LSCs can arise from both self-renewing hematopoietic stem cells (HSCs) and committed progenitor populations.
  • Showed that LSC identity is determined by the nature of oncogenic events.
  • Highlighted how oncogenic events perturb essential cellular processes like self-renewal, proliferation, differentiation, and survival.

Conclusions:

  • Mouse models are crucial for understanding leukemogenesis.
  • LSC origin is plastic and influenced by specific oncogenic mutations.
  • Insights into LSC generation can inform novel therapeutic strategies for leukemia.