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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Stem Cell Culture

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Induced Pluripotent Stem Cells

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells

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Published on: August 23, 2014

Embryonic stem cell technology: applications and uses in functional genomic studies.

Ruairi Friel¹, Dawn Fisher, Lilian Hook

¹Stem Cell Sciences Limited, Roger Land Building,West Mains Road, Edinburgh EH9 3JQ, UK. ruairi.friel@stemcellsciences.com

Stem Cell Reviews

|December 5, 2006

Summary

Embryonic stem cells are crucial for functional genomics due to their self-renewal and differentiation capabilities. Their genetic manipulability makes them valuable tools for studying gene function in various cell types.

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Area of Science:

Genomics
Developmental Biology
Stem Cell Biology

Background:

The postgenomic era demands advanced functional genomics tools.
Embryonic stem cells (ESCs) possess unique properties for these studies.

Purpose of the Study:

To discuss the applications of ESCs in functional genomics.
To highlight ESCs as valuable tools for gene function research.

Main Methods:

Utilizing ESCs' indefinite proliferation and pluripotent state.
Employing genetic manipulation techniques.
Directing in vitro differentiation of ESCs.

Main Results:

ESCs demonstrate ease of genetic manipulation.
Directed in vitro differentiation yields diverse cell types.
ESCs serve as a versatile platform for functional genomic studies.

Conclusions:

Embryonic stem cells are indispensable for modern functional genomics.
Their unique biological characteristics facilitate comprehensive gene function analysis.