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Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Related Experiment Video

Updated: Jul 18, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
04:41

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Published on: June 6, 2025

[Immobilization and hip fracture].

Yoshihiro Sato1

  • 1Mitate Hospital, Department of Neuology.

Clinical Calcium
|December 5, 2006
PubMed
Summary

Elderly stroke patients receiving folate and vitamin B12 supplements showed a significantly lower risk of hip fracture compared to placebo. This combination therapy is safe and effective for preventing fractures in this high-risk population.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Bone Metabolism

Context:

  • Hip fractures are a major cause of immobilization and mortality in the elderly, particularly those with a history of stroke.
  • Hyperhomocysteinemia is a recognized risk factor for both ischemic stroke and osteoporotic fractures in older adults.
  • Previous research indicated vitamin deficiencies (D and K1) impact bone mineral density in Alzheimer's patients.

Purpose:

  • To evaluate the efficacy of combined folate and mecobalamin (vitamin B12) supplementation in reducing hip fracture risk in elderly stroke survivors.
  • To assess the safety and impact of this nutritional intervention on homocysteine levels in a high-risk population.

Summary:

  • A randomized, double-blind study involved 628 elderly hemiplegic patients post-stroke, with 559 completing a 2-year follow-up.

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A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

Published on: May 20, 2019

Related Experiment Videos

Last Updated: Jul 18, 2026

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
04:41

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

Published on: June 6, 2025

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats
05:34

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

Published on: May 20, 2019

  • The treatment group received daily oral folate and mecobalamin, while the placebo group received double placebos.
  • Hip fractures occurred at a rate of 10 per 1,000 patient-years in the treatment group versus 43 in the placebo group (p<0.001), with a 38% reduction in homocysteine levels.

    • Impact:

    • Combined folate and vitamin B12 supplementation significantly reduces hip fracture risk in elderly stroke patients.
    • This intervention is safe and effective, offering a potential strategy for fracture prevention in a vulnerable population.
    • The findings suggest a link between homocysteine levels, stroke, and osteoporotic fractures, highlighting the importance of nutritional status in geriatric care.