Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cannonballs in <i>Trichomonas vaginalis</i> Infection: Morphologic Evidence of Parasite-Associated Neutrophilic Aggregates.

Pathogens (Basel, Switzerland)·2026

Same author

Koilocytosis in LSIL Cytology Has Limited Predictive Value for CIN2+ in HPV-Positive Women: Implications for Risk-Based Cytology Triage.

Pathogens (Basel, Switzerland)·2026

Same author

Vacuolated Parabasal Cells in Papanicolaou Smears Are Cellular Changes Caused by Human Papillomavirus 16 Infection.

Journal of medical virology·2025

Same author

Effects of hydrostatic pressure, osmotic pressure, and confinement on extracellular matrix associated responses in the nucleus pulposus cells ex vivo.

Matrix biology : journal of the International Society for Matrix Biology·2024

Same author

Bidirectionally validated <i>in silico</i> and <i>in vitro</i> formation of specific depth zone-derived chondrocyte spheroids and clusters.

Frontiers in bioengineering and biotechnology·2024

Same author

Cellular behavior and extracellular matrix turnover in bovine annulus fibrosus cells under hydrostatic pressure and deviatoric strain.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2023

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

[Bioengineering for cartilage and intervertebral disc regeneration].

Shuichi Mizuno¹

¹Brigham and Women's Hospital, Harvard Medical School, Department of Orthopedic Surgery, USA.

Clinical Calcium

|December 5, 2006

Summary

Cell-based therapies utilize optimized cells and biodegradable matrices to regenerate damaged cartilage and intervertebral discs. Bioreactors are key technologies for manipulating cell function to enhance tissue repair and restore function.

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Context:

Damaged articular cartilage and intervertebral discs require advanced therapeutic strategies.
Cell culture is essential for preparing cells for implantation, enabling control over differentiation and metabolic activity.
Bioreactor technology offers programmable control over cell culture conditions.

Purpose:

To explore the role of cell-based therapy in regenerating articular cartilage and intervertebral disc tissues.
To highlight the importance of cell culture and bioreactor technology in optimizing cell function for tissue regeneration.
To integrate current biochemical, molecular, and clinical insights into bioengineering approaches for secure and functional tissue restoration.

Summary:

More Related Videos

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant

Published on: September 7, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant

Published on: September 7, 2016

Cell-based therapies employ optimized cells and biodegradable matrices to promote the regeneration of damaged or degenerative articular cartilage and intervertebral disc tissues.

Cell culture is a critical step for constructing engineered tissues, providing the sole means to modulate cell differentiation and metabolic function before implantation.

Bioreactors represent a key technology, enabling programmed adjustments to culture conditions to maximize tissue regeneration outcomes.

Impact:

Bioengineering strategies, informed by the latest scientific advancements, offer promising avenues for secure treatments to restore functional tissues.
This approach has the potential to significantly improve outcomes for patients with cartilage and intervertebral disc degeneration.
Advancements in cell culture and bioreactor technology are crucial for the successful clinical translation of tissue engineering therapies.