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Databases of free expression.

John R Walker1, Tim Wiltshire

  • 1Genomics Institute of Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA. walker@gnf.org

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|December 5, 2006
PubMed
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Public gene expression databases offer valuable resources for researchers studying gene expression regulation. This review categorizes and highlights features of mammalian microarray databases, focusing on tissue expression and data warehouses.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Microarray technology has advanced rapidly, driving progress in gene expression analysis.
  • Public gene expression databases are crucial resources for researchers.
  • These databases support various applications, including data analysis and regulatory studies.

Purpose of the Study:

  • To review current features of public gene expression databases.
  • To categorize mammalian microarray databases into tissue-specific and data warehouse types.
  • To provide examples of each database category.

Main Methods:

  • Literature review of existing public gene expression databases.
  • Categorization based on content, analysis capabilities, and usability.

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  • Highlighting features of tissue gene expression databases and data warehouses.

    • Main Results:

    • A diverse landscape of public gene expression databases exists.
    • Databases vary significantly in content, analytical functions, and user-friendliness.
    • Two primary categories of mammalian microarray databases are identified: tissue databases and data warehouses.

    Conclusions:

    • Public gene expression databases are essential tools for biological research.
    • Understanding database types (tissue vs. data warehouse) aids researchers in selecting appropriate resources.
    • This review provides a framework for navigating the available gene expression database landscape.