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Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
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Related Experiment Video

Updated: Jul 18, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Post-traumatic bacterial keratitis--a microbiological prospective clinical study.

C Stefan1, A Nenciu

  • 1Department of Ophthalmology, Emergency Central Clinical Military Hospital Bucharest, Romania. cstefan58@yahoo.com

Oftalmologia (Bucharest, Romania : 1990)
|December 6, 2006
PubMed
Summary

Traumatic bacterial keratitis, often caused by Gram-positive bacteria like Staphylococcus epidermidis, requires prompt management. While most ulcers resolve, visual outcomes vary, highlighting the need for effective antimicrobial strategies.

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Last Updated: Jul 18, 2026

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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Infectious keratitis is a significant cause of vision loss.
  • Ocular trauma is the primary risk factor for bacterial keratitis.
  • Understanding the microbiological and clinical characteristics of traumatic bacterial keratitis is crucial for effective treatment.

Purpose of the Study:

  • To define the microbiological and clinical profile of traumatic bacterial keratitis.
  • To analyze the management strategies and outcomes for patients with this condition.

Main Methods:

  • Prospective enrollment of 68 patients with traumatic bacterial keratitis.
  • Analysis of clinical features, including age, risk factors, visual acuity, and corneal ulcer size.
  • Microbiological profiling through corneal scraping and analysis of bacterial isolates.

Main Results:

  • Corneal scraping yielded positive results in 86.7% of cases.
  • Gram-positive bacteria, particularly Staphylococcus epidermidis (41.7%), were the most common pathogens.
  • Gram-negative bacteria were associated with more severe inflammation and larger infiltrates. While 95.5% of ulcers resolved, only 75% of patients achieved improved visual acuity, with 4.4% requiring corneal transplants.

Conclusions:

  • Ocular trauma is a major risk factor for bacterial keratitis.
  • Corneal ulcer size is a significant predictor of positive culture results and correlates with patient age.
  • Fluoroquinolones are often a first-line therapy, but in vitro resistance necessitates careful monitoring and potential adjustments based on culture results.