Related Experiment Video

Updated: Jul 18, 2026

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

[Familial combined hyperlipidemia, metabolic syndrome and cardiovascular disease]

Sergio Martinez-Hervás1, José T Real, Antonia Priego

  • 1Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Universidad de Valencia, Valencia, Spain.

Revista Espanola De Cardiologia
|December 6, 2006
PubMed

Insights

Metabolic syndrome is a significant cardiovascular risk marker in patients with familial combined hyperlipidemia (FCH). This study found a higher prevalence of metabolic syndrome in FCH patients who survived myocardial infarction.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Genetics

Background:

  • Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder.
  • Cardiovascular disease (CVD), particularly myocardial infarction (MI), is a major concern in FCH patients.
  • The role of metabolic syndrome in CVD risk stratification within FCH populations requires further elucidation.

Purpose of the Study:

  • To investigate the association between metabolic syndrome and cardiovascular disease events, specifically myocardial infarction (MI) survivors.
  • To compare the prevalence of metabolic syndrome in FCH patients with a history of MI versus those without MI and healthy controls.
  • To determine if metabolic syndrome serves as a cardiovascular risk marker in individuals with FCH.

Main Methods:

  • Comparative study involving three groups: FCH patients with MI survivors (n=20), FCH patients without MI (n=20), and matched controls (n=20).
  • Assessment of plasma lipid, glucose, and insulin levels.
  • Diagnosis of metabolic syndrome using World Health Organization (WHO) and National Cholesterol Education Program-Adult treatment panel (NCEP-ATPIII) criteria.
  • Statistical analysis using non-parametric tests and logistic regression.

Main Results:

  • Metabolic syndrome was diagnosed in 19/20 FCH patients with MI survivors, 11/20 FCH patients without MI, and 6/20 control subjects (P<.001) based on WHO criteria.
  • A significantly higher prevalence of metabolic syndrome was observed in FCH patients with a history of MI compared to those without MI (P<.01).
  • Logistic regression analysis indicated that metabolic syndrome is associated with ischemic coronary disease in this cohort.

Conclusions:

  • The presence of metabolic syndrome is significantly more common in FCH patients who have experienced a myocardial infarction.
  • Metabolic syndrome, as defined by WHO criteria, acts as a valuable cardiovascular risk marker in individuals with familial combined hyperlipidemia.
  • Early identification and management of metabolic syndrome components are crucial for mitigating CVD risk in FCH patients.

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...