Related Experiment Video
Updated: Jul 18, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Non-neoplastic conditions presenting as soft-tissue tumours
N Crundwell1, P O'Donnell, A Saifuddin
1Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK.
Clinical Radiology
|December 6, 2006
Summary
Many soft-tissue lesions referred as tumors are actually non-neoplastic. This review highlights key imaging features to distinguish these benign conditions from actual soft-tissue neoplasms.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Soft-tissue tumors are a common referral concern.
- Accurate differentiation between neoplastic and non-neoplastic lesions is crucial for patient management.
- Imaging plays a pivotal role in the initial assessment of soft-tissue lesions.
Purpose of the Study:
- To analyze the frequency of non-neoplastic lesions misdiagnosed as soft-tissue tumors.
- To present the characteristic imaging findings of common non-neoplastic soft-tissue lesions.
- To aid radiologists in differentiating benign conditions from neoplasms.
Main Methods:
- Retrospective review of approximately 750 soft-tissue lesion referrals over 7 years.
- Analysis of imaging characteristics for lesions ultimately diagnosed as non-neoplastic.
- Categorization of common and rarer non-neoplastic diagnoses.
Main Results:
- 132 out of 750 (approx. 17.6%) referred soft-tissue tumors were non-neoplastic.
- Most common non-neoplastic diagnoses included myositis ossificans, ganglion cysts, abscesses/infections, bursitis, and synovitis.
- Distinct imaging patterns were identified for these benign entities.
Conclusions:
- A significant proportion of soft-tissue lesions referred for tumor evaluation are non-neoplastic.
- Understanding the imaging features of common non-neoplastic lesions is essential for accurate diagnosis.
- This can help reduce unnecessary biopsies and guide appropriate patient care.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:28Disorders of the Skeletal Muscle
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...