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Updated: Jul 18, 2026
06:35
In vivo Evaluation of Mucociliary Clearance in Mice
Published on: December 18, 2020
Single dose oral ranitidine improves MRCP image quality: a double-blind study.
M T Bowes1, D F Martin, A Melling
1South Manchester University Hospitals NHS Trust, Wythenshawe, Manchester, UK.
Clinical Radiology
|December 6, 2006
Summary
A single oral dose of ranitidine before magnetic resonance cholangiopancreatography (MRCP) significantly reduces stomach and duodenum signal. This improves the visibility of the biliary tree, aiding in diagnosis.
Area of Science:
- Radiology
- Gastroenterology
- Pharmacology
Background:
- Magnetic resonance cholangiopancreatography (MRCP) is a key imaging technique for evaluating the biliary tree.
- Signal from the stomach and duodenum can obscure visualization of the distal common bile duct.
Purpose of the Study:
- To assess if a single 300 mg oral dose of ranitidine can reduce upper gastrointestinal signal.
- To determine if ranitidine improves the conspicuity of the biliary tree during MRCP.
Main Methods:
- A double-blind, placebo-controlled, randomized crossover trial involving 35 volunteers.
- MRCP was performed using a 1.5 T MRI scanner.
- Examinations were scored by experienced consultants for image quality.
Main Results:
- Ranitidine significantly decreased signal intensity in the stomach and duodenum (p<0.0005).
- Conspicuity of the distal and proximal common bile duct significantly increased (p<0.033 and p<0.010, respectively).
- No adverse effects were reported.
Conclusions:
- Ranitidine is an effective and inexpensive agent for reducing upper gastrointestinal signal.
- Oral ranitidine enhances the visibility of the biliary tree in MRCP examinations.
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