Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world Safety and Performance of the Symani Surgical System® in Microsurgical Reconstructive Procedures: Primary Results from the PRIMO Study.

Annals of surgery·2026

Same author

Congestion … Sinister … Vena Amoris … and the LOVE ♥ of Microsurgery.

Archives of plastic surgery·2026

Same author

Clinical Images: A thorn injury, a sea-borne culprit, and a tenosynovitis dilemma.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

First Metatarsal Reconstruction After Resection for Musculoskeletal Tumors: A Technical Tip Using Vascularized Fibula.

Foot & ankle orthopaedics·2026

Same author

A Baton for Karaoke Intertwined with The Blade of The Surgeon.

Archives of plastic surgery·2025

Same author

Histological and proteomic characterization of musculoskeletal amyloidomas.

Pathologica·2025

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

Vascularized epiphyseal transplant.

Marco Innocenti¹, Luca Delcroix, G Federico Romano

¹Microsurgery Unit, Department of Orthopaedics, Azienda Ospedaliera-Universitaria Careggi, Largo Palagi 1, Firenze 50139, Italy. m.innocenti@agora.it

The Orthopedic Clinics of North America

|December 6, 2006

Summary

Vascularized fibular epiphysis transfer can restore limb length in children with bone defects. This technique shows promise for growth potential and preventing limb length discrepancy in pediatric patients.

More Related Videos

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

Published on: October 14, 2013

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

Published on: October 14, 2013

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Area of Science:

Orthopedic Surgery
Pediatric Orthopedics
Vascularized Tissue Transfer

Background:

Limb length discrepancy is a common complication in skeletally immature patients with large bone defects.
Traditional reconstructive methods may not preserve growth potential, leading to long-term functional deficits.
Vascularized tissue transfer offers a potential solution for bone reconstruction while maintaining growth capacity.

Purpose of the Study:

To evaluate the efficacy of vascularized proximal fibular epiphysis transfer in reconstructing large bone defects in pediatric patients.
To assess the growth potential of the transferred graft and its impact on preventing limb length discrepancy.
To determine the indications and limitations of this reconstructive technique.

Main Methods:

A retrospective review of 27 skeletally immature patients (ages 2-11 years) who underwent vascularized proximal fibular epiphysis transfer.
Reconstruction of large bone defects involving the epiphysis.
Follow-up ranging from 2 to 14 years to assess graft viability, growth, and limb length.

Main Results:

The vascularized proximal fibular epiphysis transfer was successfully performed in all 27 patients.
The grafts demonstrated viable incorporation and potential for longitudinal growth.
Limb length discrepancy was effectively managed or prevented in the majority of cases.
The procedure showed promising functional outcomes and patient satisfaction.

Conclusions:

Vascularized proximal fibular epiphysis transfer is a viable reconstructive option for large bone defects in skeletally immature patients.
This technique preserves growth potential and effectively addresses limb length discrepancy.
Further research is warranted to fully elucidate the long-term outcomes and refine indications for this procedure.