Assesment criteria for experimental demyelination induced in frog peripheral nerve

In ideal conditions the area under compound action potential may be used as an index for the number of activated fibers in a nerve trunk whereas peak amplitude, maximum time derivative, and duration may be used as an indicator for the rate of contribution to compound action potential and the degree of velocity dispersion. In this study, the time domain effect of demyelination on compound action potential has been investigated in experimentally demyelinated frog sciatic nerve. The results were analyzed in order to suggest criteria for demyelination. The results suggest that the changes in peak amplitude and maximum time derivative of compound action potential that is made up by the contribution of the active fibers may be more useful in the assessment of early phase of demyelination. Therefore, it may be concluded that these two parameters, intrinsically, carry augmented information on the velocity dispersion originated from larger-diameter fibers.