Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IntAct--open source resource for molecular interaction data.

S Kerrien1, Y Alam-Faruque, B Aranda

  • 1EMBL Outstation-European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. skerrien@ebi.ac.uk

Nucleic Acids Research
|December 6, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An enhanced workflow for variant interpretation in UniProtKB/Swiss-Prot improves consistency and reuse in ClinVar.

Database : the journal of biological databases and curation·2019
Same author

Encompassing new use cases - level 3.0 of the HUPO-PSI format for molecular interactions.

BMC bioinformatics·2018
Same author

Severe anaphylaxis to Propofol: first case of evidence of sensitization to soy oil.

European annals of allergy and clinical immunology·2016
Same author

(Partial) Loss of BAF250a (ARID1A) in rectovaginal deep-infiltrating endometriosis, endometriomas and involved pelvic sentinel lymph nodes.

Molecular human reproduction·2016
Same author

[Computed tomographic anatomy of the salivary glands in the cat].

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2016
Same author

[Direct Drive Simulation - Sound-Simulation of the Vibrant Soundbridge®].

Laryngo- rhino- otologie·2015
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles
This summary is machine-generated.

IntAct is a free, open-source database for molecular interaction data, manually curated from scientific literature. It offers tools for searching, visualizing, and downloading over 126,000 interactions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Molecular interaction data is crucial for understanding cellular processes.
  • Manual curation from literature ensures high data quality and detail.
  • Existing databases require robust tools for data management and accessibility.

Purpose of the Study:

  • To present IntAct, an open-source resource for molecular interaction data.
  • To highlight the manual curation process and data richness.
  • To provide web-based tools for data access and analysis.

Main Methods:

  • Data extraction from over 2100 scientific publications.
  • Manual annotation by expert biologists, including experimental details.
  • Development of a database and software suite for data storage and analysis.

Related Experiment Videos

Main Results:

  • The IntAct database contains over 126,000 binary molecular interactions.
  • Extensive use of controlled vocabularies ensures data consistency.
  • Web tools enable searching, visualization, and downloading of interaction data.

Conclusions:

  • IntAct serves as a valuable, high-quality resource for molecular interaction data.
  • The open-source nature and collaborative features promote data sharing and reuse.
  • IntAct facilitates research in molecular biology and systems biology.