RNAdb 2.0--an expanded database of mammalian non-coding RNAs

Area of Science:

• Genomics
• Molecular Biology
• Bioinformatics

Background:

• Non-protein-coding RNAs (ncRNAs) are increasingly recognized for their crucial regulatory roles in multicellular organisms.
• The discovery of novel ncRNAs and their functions is rapidly expanding.

Purpose of the Study:

• To update RNAdb with comprehensive mammalian non-protein-coding RNA data.
• To provide nucleotide sequences, annotations, and expression data for a wide range of ncRNAs.

Main Methods:

• Curated nucleotide sequences and annotations for tens of thousands of non-housekeeping ncRNAs.
• Inclusion of microRNAs, small nucleolar RNAs, PIWI-interacting RNAs, and other predicted ncRNAs.
• Integration of microarray-based expression data and links to specialized resources like miRBase.

Main Results:

• RNAdb now contains extensive data for numerous mammalian ncRNAs, including those with known and unknown functions.
• The database includes diverse ncRNA types, from microRNAs to putative antisense transcripts.
• Enhanced data accessibility through updated datasets and improved integration with other ncRNA resources.

Conclusions:

• The updated RNAdb provides a valuable resource for studying the regulatory functions of mammalian ncRNAs.
• This comprehensive database supports ongoing research into ncRNA discovery and functional characterization.
• RNAdb facilitates deeper investigation into the significance of various ncRNA classes in biological processes.