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10:49
Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Bacterial efflux pump inhibitors from natural sources
Michael Stavri1, Laura J V Piddock, Simon Gibbons
1Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London 29-39 Brunswick Square, London, UK.
The Journal of Antimicrobial Chemotherapy
|December 6, 2006
Summary
Multidrug resistance (MDR) in bacteria is a growing threat. This review explores plant-derived efflux pump inhibitors (EPIs) as a strategy to combat MDR and restore antibiotic effectiveness.
Area of Science:
- Microbiology
- Pharmacology
- Natural Products Chemistry
Background:
- Multidrug resistance (MDR) in bacteria, driven by efflux pumps, compromises antibiotic efficacy.
- Efflux pumps actively expel diverse compounds, including critical antibiotics, leading to therapeutic failure.
- Rapid evolution of resistance necessitates novel antibacterial and resistance-modifying agents.
Purpose of the Study:
- To review natural product-derived bacterial efflux pump inhibitors (EPIs).
- To highlight the potential of EPIs in combating MDR bacterial infections.
- To assess EPIs as leads for future clinical development.
Main Methods:
- Literature review of scientific publications on bacterial efflux pumps and EPIs.
- Focus on EPIs derived from natural sources, particularly plants.
- Analysis of resistance-modifying activities and clinical potential.
Main Results:
- Efflux pumps are key contributors to bacterial multidrug resistance.
- Numerous chemical classes of EPIs have been identified from natural sources.
- EPIs show promise in restoring sensitivity to existing antibiotics and preventing resistance.
Conclusions:
- Bacterial efflux pump inhibitors (EPIs) are crucial for addressing the MDR crisis.
- Plant-derived EPIs represent a promising avenue for novel therapeutic strategies.
- Further research into EPIs is warranted for clinical development to combat MDR strains.
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