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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 18, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

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Preparing the "soil": the premetastatic niche.

Rosandra N Kaplan1, Shahin Rafii, David Lyden

  • 1Department of Pediatrics, Weill College of Medicine at Cornell University, New York, NY 10021, USA.

Cancer Research
|December 6, 2006
PubMed
Summary

The premetastatic niche, formed by bone marrow cells before tumor cell arrival, is crucial for cancer metastasis. Targeting these early cellular events may help detect and prevent cancer spread.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Current cancer metastasis research primarily focuses on intrinsic tumor cell factors.
  • The formation of a "premetastatic niche" in distant tissues precedes tumor cell arrival.
  • This niche involves fibronectin upregulation and bone marrow-derived cell infiltration.

Purpose of the Study:

  • To investigate the role of the premetastatic niche in cancer metastasis.
  • To understand the early cellular and molecular events driving metastatic spread.
  • To identify potential targets for early detection and prevention of metastasis.

Main Methods:

  • Analysis of fibronectin expression and matrix metalloproteinases in distant tissues.
  • Characterization of bone marrow-derived hematopoietic progenitors expressing vascular endothelial growth factor receptor 1.

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Last Updated: Jul 18, 2026

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  • Investigation of growth factor signaling from primary tumors to mobilize progenitor cells.

    • Main Results:

    • Specific upregulation of fibronectin and matrix metalloproteinases occurs before tumor cell arrival.
    • Bone marrow-derived cells expressing vascular endothelial growth factor receptor 1 mobilize in response to tumor-derived growth factors.
    • These cellular infiltrates establish a premetastatic niche that influences metastatic patterns.

    Conclusions:

    • The premetastatic niche is indispensable for the initial stages of metastasis.
    • Early detection and prevention strategies should focus on these pre-metastatic events.
    • Understanding the premetastatic niche opens new avenues for therapeutic intervention in cancer dissemination.