Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconstruction of a Bis(bibenzyl) Biosynthetic Pathway through Analysis of 4-Coumarate:CoA Ligase and Double-Bond Reductase in Marchantia polymorpha.

Plant & cell physiology·2026
Same author

Dimeric boron complexes bearing isoquinolyl-pyrrole ligands.

Chemical communications (Cambridge, England)·2025
Same author

Near-complete de novo assembly of Tricholoma bakamatsutake chromosomes revealed the structural divergence and differentiation of Tricholoma genomes.

G3 (Bethesda, Md.)·2023
Same author

Automated cell culture system for the production of cell aggregates with growth plate-like structure from induced pluripotent stem cells.

SLAS technology·2023
Same author

Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart.

Stem cell reports·2023
Same author

Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model.

Scientific reports·2023

Related Experiment Videos

Accelerated decrease in bone mineral density in women aged 52-57 years.

Takahiko Nohara1, Tsutomu Kamei, Akira Ohta

  • 1Health Administration Center Izumo, Shimane University, Faculty of Medicine, Izumo, Japan. nohara@med.shimane-u.ac.jp

The Tohoku Journal of Experimental Medicine
|December 6, 2006
PubMed
Summary

Bone mineral density (BMD) in women shows a sharp decline between ages 52-57, followed by a gradual decrease. This finding aids in predicting bone density changes and preventing osteoporosis.

Related Experiment Videos

Area of Science:

  • Gerontology
  • Bone Physiology
  • Medical Imaging

Background:

  • Bone mineral density (BMD) is known to decrease in middle-aged and elderly individuals.
  • The precise age of onset and rate of BMD decline remain unclear.
  • Understanding these patterns is crucial for osteoporosis prevention.

Purpose of the Study:

  • To investigate the association between age and mean bone mineral density (BMD) in women.
  • To identify specific age ranges where BMD decline accelerates.
  • To establish a predictive model for BMD changes relative to age.

Main Methods:

  • Dual-energy x-ray absorptiometry (DXA) was used to measure BMD.
  • Measurements were taken of lumbar vertebrae (n=1,167) and the entire skeleton (n=1,038).
  • Study participants ranged from 30 to 70 years of age.

Main Results:

  • BMD showed minimal change in women aged 30-51 years.
  • A significant, sharp decrease in BMD occurred between 52 and 57 years of age.
  • After age 58, BMD decline became gradual.

Conclusions:

  • BMD declines more rapidly in women aged 52-57 years compared to those 58 and older.
  • Endocrine factors likely influence age-related bone density decrease.
  • The derived regression line can predict BMD and aid in osteoporosis prevention strategies.