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Related Experiment Videos

Prenatal diagnosis: progress through plasma nucleic acids.

Y M Dennis Lo1, Rossa W K Chiu

  • 1Li Ka Shing Institute of Health Sciences and the Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 3032 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China. loym@cuhk.edu.hk

Nature Reviews. Genetics
|December 6, 2006
PubMed
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Non-invasive prenatal diagnosis has advanced significantly due to the discovery of fetal nucleic acids in maternal plasma since 1997. New genetic, epigenetic, and gene-expression markers are poised to revolutionize prenatal testing.

Area of Science:

  • Obstetrics and Gynecology
  • Genetics
  • Molecular Biology

Background:

  • Significant research efforts over 40 years have focused on developing non-invasive prenatal diagnostic methods.
  • The discovery of extracellular fetal nucleic acids in maternal plasma since 1997 has accelerated progress.
  • This field is crucial for improving prenatal care and reducing invasive procedures.

Purpose of the Study:

  • To review the advancements in non-invasive prenatal diagnosis.
  • To highlight the impact of extracellular fetal nucleic acids on the field.
  • To discuss the potential of novel markers in prenatal genetic testing.

Main Methods:

  • Review of scientific literature on non-invasive prenatal diagnosis.
  • Analysis of key findings related to extracellular fetal nucleic acids.

Related Experiment Videos

  • Identification and categorization of novel genetic, epigenetic, and gene-expression markers.

    • Main Results:

    • The detection of extracellular fetal nucleic acids in maternal plasma has been a pivotal development.
    • Numerous novel markers have been identified and validated.
    • These markers offer new avenues for genetic, epigenetic, and gene-expression analysis.

    Conclusions:

    • Non-invasive prenatal diagnosis has undergone rapid evolution, driven by molecular discoveries.
    • Extracellular fetal nucleic acids provide a powerful tool for prenatal genetic assessment.
    • Future prenatal diagnosis practices are expected to be fundamentally transformed by these advancements.