Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast
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V Eusebi1, M G Cattani, J Lamovec
1Institute of Anatomic Pathology, University of Bologna, Italy.
Ultrastructural Pathology
|May 1, 1991
Abstract:
Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.