Related Experiment Video
Updated: Jul 18, 2026
04:56
Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Coagulation disorders and stroke]
J A Zeller1, Ch C Eschenfelder, R Stingele
1Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Schittenhelmstrasse 10, 24105 Kiel.
Hamostaseologie
|December 6, 2006
Summary
Identifying prothrombotic clotting disorders in acute ischemic stroke is crucial. A tailored diagnostic approach is recommended for patients with specific risk factors to manage these rare conditions effectively.
Area of Science:
- Neurology
- Hematology
- Genetics
Context:
- Acute ischemic stroke pathophysiology.
- Coagulation disorders (hereditary and acquired) as potential contributors.
- Need for a targeted diagnostic strategy due to low prevalence and high costs.
Purpose:
- To outline the role of coagulation disorders in acute ischemic stroke.
- To identify clinical indicators suggestive of prothrombotic clotting disorders.
- To discuss specific coagulation abnormalities relevant to stroke.
Summary:
- Coagulation disorders are implicated in acute ischemic stroke.
- Suggestive factors include young patient age, recurrent thrombosis, premature atherosclerosis, recurrent miscarriages, and cardiac abnormalities like patent foramen ovale.
- Specific disorders discussed include antithrombin III, protein C, protein S deficiencies, APC-resistance, prothrombin mutation, hyperhomocysteinemia, antiphospholipid antibodies, and cellular procoagulant interactions.
Impact:
- Guides clinicians in selecting appropriate diagnostic tests for stroke patients.
- Facilitates early identification and management of thrombotic risks.
- Improves patient outcomes by addressing underlying prothrombotic states.
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