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Elevated levels of c-jun and c-fos transcripts in the aged rat liver
1Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan.
Biochemical and Biophysical Research Communications
|August 15, 1991
Abstract:
Age-associated increases of transcript levels of several genes were studied using aged rat liver. Northern hybridization showed marked increases of c-jun, c-fos, and glutathione S-transferase P (GST-P) in 24-month-old rats. These genes have the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-responsive element called TRE in their structures. Thus, TRE seems to be involved in important age-associated changes of gene expression.