Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Red hair--a desirable mutation?

Thomas Ha1, Jonathan L Rees

  • 1Department of Dermatology, University of Edinburgh, Edinburgh, UK. Tha@ed.ac.uk

Journal of Cosmetic Dermatology
|December 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association of body mass index with patient outcomes after shoulder replacement surgery: Population-based cohort study using linked national data from the United Kingdom and Denmark.

PLoS medicine·2025
Same author

Variations in surgical practice and adverse events following isolated proximal humerus fracture in adults - a comparative longitudinal cohort study of 53,852 patients from Denmark, England, and Sweden.

BMC medicine·2025
Same author

Evaluation of comorbidity measures for predicting mortality and revision surgery after elective primary shoulder replacement surgery based on data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study.

BMJ medicine·2025
Same author

GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as an adjunct to extended duration pharmacological thromboprophylaxis for venous thromboembolism prevention.

BMJ open·2025
Same author

A comparative study of shoulder replacement outcomes using linked national registry and hospital data from England and Denmark.

BMC medicine·2025
Same author

Analytical and Clinical Validation of the Oncomine Dx Target Test to Assess HER2 Mutation Status in Tumor Tissue Samples From Patients With Non-Small Cell Lung Cancer Treated With Trastuzumab Deruxtecan in the DESTINY-Lung01 and DESTINY-Lung02 Studies.

Archives of pathology & laboratory medicine·2024

Red hair results from mutations in the melanocortin-1 receptor (MC1R) gene, altering pigment production. This review explores MC1R

Area of Science:

  • Genetics
  • Human Physiology
  • Dermatology

Background:

  • Red hair is a striking human hair color variant with historical social significance.
  • The genetic basis of red hair involves specific mutations.
  • Melanocortin-1 receptor (MC1R) plays a crucial role in pigment production.

Purpose of the Study:

  • To review the discovery of MC1R in animal coat color.
  • To examine the role of MC1R in human physiology.
  • To explore the potential involvement of MC1R in human skin carcinogenesis and historical development.

Main Methods:

  • Literature review of MC1R discovery and function.
  • Analysis of genetic mutations affecting MC1R.
  • Synthesis of research on MC1R's role in pigmentation and health.

Related Experiment Videos

Main Results:

  • Loss-of-function mutations in MC1R lead to red hair by favoring pheomelanin over eumelanin.
  • MC1R is critical for determining human hair and skin pigmentation.
  • MC1R's influence extends to potential roles in skin cancer and human evolution.

Conclusions:

  • MC1R gene mutations are the primary cause of red hair in humans.
  • Understanding MC1R function is key to comprehending human pigmentation.
  • Further research into MC1R's broader physiological and pathological roles is warranted.