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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

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A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
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Nutraceuticals: potential roles and potential risks for pain management.

Alan D Kaye1, Adam M Kaye, Amr Hegazi

  • 1Department of Anesthesiology, Texas Tech University School of Medicine, Lubbock, Texas 79430, USA.

Pain Practice : the Official Journal of World Institute of Pain
|December 7, 2006
PubMed
Summary

Many patients use herbal supplements, but few disclose this to doctors, posing bleeding risks. Understanding herb-drug interactions is crucial for safe pain management and surgical care.

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Last Updated: Jul 18, 2026

A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

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Published on: April 14, 2016

Area of Science:

  • Pharmacology
  • Herbal Medicine
  • Anesthesiology

Background:

  • The global market has seen a surge in over-the-counter herbal products (nutraceuticals).
  • Despite lack of conventional endorsement, daily use of these supplements is increasing.
  • A significant percentage of surgical patients use herbal supplements, often without disclosure during anesthetic assessments.

Purpose of the Study:

  • To review the mechanisms of coagulation.
  • To correlate the role of commonly used herbs with potential bleeding side effects.
  • To explore herbal agents for pain management.

Main Methods:

  • Review of basic coagulation mechanisms.
  • Correlation of known bleeding side effects of common herbs.
  • Literature review of herbal pain management agents.

Main Results:

  • Certain commonly used herbs possess side effects that can lead to excessive bleeding.
  • Understanding these interactions is vital for pain physicians.
  • Several herbal-derived agents show potential for pain management.

Conclusions:

  • Patients' undisclosed use of herbal supplements presents a bleeding risk during procedures.
  • Pain physicians must be aware of potential herb-induced coagulation issues.
  • Further research into safe and effective herbal pain management is warranted.