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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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Proliferation of resting lymphocytes is induced by triggering T cells through an epitope common to the three

V David1, G Leca, N Corvaia

  • 1Unité INSERM U 93, Hopital Saint-Louis, Paris, France.

Cellular Immunology
|September 1, 1991
PubMed

LFA-1, Mac-1, and p150,95 are a family of functionally important leucocyte integrins that share a common beta-subunit and participate in cellular adhesion. Monoclonal antibody to LFA-1 were described to block T-cell-mediated killing by inhibiting adhesion to target cells and to decrease T cell responses by preventing cell-cell contact. Recently it was demonstrated that LFA-1 molecule was involved in signal transduction. We report here that a monoclonal antibody termed 6.7 reacting with the three members of the leucocyte integrins is able in the presence of monocytes to directly induce the proliferation of resting peripheral blood T cells obtained from normal individuals. These results suggest the possibility that LFA-1 molecules could trigger T lymphocyte activation in addition to their role in homing, growth, and differentiation.

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