Neurodevelopmental outcome of the late preterm infant
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Updated: Jul 18, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
1Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, GA 30303, USA. ira_adams-chapman@oz.ped.emory.edu
Insights
Late preterm infants face developmental risks due to brain vulnerability. Careful neurologic monitoring is crucial for these infants to mitigate potential brain injury risks.
Area of Science:
- Neonatal neurology
- Developmental pediatrics
- Fetal neurodevelopment
Background:
- Late preterm infants (born between 34 and 36 6/7 weeks gestation) have limited documented developmental outcomes.
- The developing brain is highly susceptible to injury during late fetal development.
- Understanding risks for this population is critical.
Purpose of the Study:
- To review the current understanding of gestational brain development.
- To identify complications of late preterm birth that increase the risk of brain injury.
- To emphasize the importance of neurologic outcome monitoring in late preterm infants.
Main Methods:
- Literature review of studies on late preterm infant neurodevelopment.
- Analysis of factors contributing to brain injury in this population.
- Synthesis of information on gestational brain development.
Main Results:
- Limited data exists on the long-term developmental outcomes for late preterm infants.
- Specific complications of late preterm birth can significantly elevate the risk of brain injury.
- The late preterm period is a critical window for fetal brain development and vulnerability.
Conclusions:
- Neurologic outcome monitoring is essential for late preterm infants.
- Further research is needed to fully understand developmental trajectories.
- Preventive strategies targeting brain injury risks should be prioritized.
Abstract:
There is very limited information about the developmental outcome of the late preterm infant. The developing brain is vulnerable to injury during this very active and important stage of fetal brain development; therefore, it is important to carefully monitor the neurologic outcome of these infants. This article discusses gestational brain development and complications of late preterm birth that contribute to the overall risk of brain injury.
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