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Updated: Jul 18, 2026

T Cells Capture Bacteria by Transinfection from Dendritic Cells
Published on: January 13, 2016
Pathology during acute infections: contributions of intracellular pathogens and the CTL response
Vitaly V Ganusov1, Rustom Antia
1Department of Biology, Emory University, Atlanta, GA 30322, USA. vitaly.ganusov@alum.emory.edu
Abstract:
Previous work has shown how, in the case of cytotoxic T-lymphocyte (CTL) responses to persistent viral infections, pathology may arise as a consequence of cell destruction directly by the virus or indirectly due to the CTL response, leading to maximum pathology at intermediate efficacy of the immune response. We expand these studies to consider pathology arising during acute infections with intracellular pathogens controlled by the CTL response. We show that, in contrast to persistent infections, pathology during acute infections is minimized with increasing efficacy of the immune response. The implications of these results for vaccination are discussed.
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