Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conserved residues in the Gα interface show subtype specificity in Gβγ coupling.

The Journal of biological chemistry·2026
Same author

Determinants of drug efficacy and the dynamics of G protein activation.

Nature structural & molecular biology·2026
Same author

Scope evolution at the journal of biological chemistry: Advancing molecular insight in a changing scientific landscape.

The Journal of biological chemistry·2026
Same author

Conserved Residues in the Gα interface show subtype specificity in Gβγ coupling.

bioRxiv : the preprint server for biology·2026
Same author

Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.

Molecular biology of the cell·2025
Same author

Non-redundant roles for paralogous proteins in the yeast glucose-sensing pathway.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jul 18, 2026

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells
07:59

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

Pheromone signaling pathways in yeast.

Henrik G Dohlman1, Janna E Slessareva

  • 1Department of Biochemistry and Biophysics, Mary Ellen Jones Building Room 430, University of North Carolina, Chapel Hill, NC 27599-7260, USA. henrik_dohlman@med.unc.edu

Science'S STKE : Signal Transduction Knowledge Environment
|December 7, 2006
PubMed
Summary

Yeast studies reveal key components of cell signaling pathways, including G protein-coupled receptors and mitogen-activated protein kinase cascades. These findings advance our understanding of cellular communication and pathway regulation.

More Related Videos

Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

Assay for Adhesion and Agar Invasion in S. cerevisiae
04:36

Assay for Adhesion and Agar Invasion in S. cerevisiae

Published on: November 8, 2006

Related Experiment Videos

Last Updated: Jul 18, 2026

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells
07:59

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

Assay for Adhesion and Agar Invasion in S. cerevisiae
04:36

Assay for Adhesion and Agar Invasion in S. cerevisiae

Published on: November 8, 2006

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Extracellular stimuli are often mediated by complexes involving cell surface receptors, heterotrimeric guanine nucleotide-binding proteins (G proteins), and mitogen-activated protein kinase (MAPK) cascades.
  • Haploid yeast cells and their response to peptide mating pheromones have been instrumental in deciphering G protein and MAPK signaling mechanisms.

Purpose of the Study:

  • To update the understanding of G protein and MAPK signaling pathways.
  • To incorporate new findings on pathway components, interactions, and cellular localization.

Main Methods:

  • Analysis of haploid yeast cells and their response to peptide mating pheromones.
  • Utilizing genomic, proteomic, and computational approaches in yeast.
  • Updating the Connections Map in the Database of Cell Signaling.

Main Results:

  • Yeast studies have identified crucial components and regulators of G protein and MAPK signaling, including the role of G protein betagamma subunits and the three-tiered MAPK module.
  • The concept of kinase-scaffold proteins and the first regulator of G protein signaling protein were discovered in yeast.
  • New pathway components and interactions have been uncovered, some located in unexpected cellular compartments.

Conclusions:

  • Yeast serves as a powerful model system for dissecting complex cell signaling pathways.
  • Advances in yeast research continue to reveal novel aspects of G protein and MAPK signaling.
  • The updated Connections Map reflects significant revisions to this fundamental signal response pathway.