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Updated: Jul 18, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
Rheumatoid arthritis-associated necrotizing scleritis and peripheral ulcerative keratitis treated successfully with
Ismael I Atchia1, C Elizabeth Kidd, R W D Bell
1Education Centre, Wansbeck General Hospital/Northumbria NHS Trust, Northumberland, UK. ish@doctors.org.uk
Abstract:
In patients with rheumatoid arthritis (RA), necrotizing scleritis, an ocular manifestation of a systemic vasculitic process, is associated with significant ocular morbidity and high mortality. We present a 60-year-old man with RA who developed necrotizing scleritis and peripheral ulcerative keratitis. The scleritis was refractory to local measures, systemic corticosteroids, and cyclophosphamide but responded rapidly to infliximab. Our case illustrates that biologic agents may be considered in refractory cases of sight- and life-threatening scleritis.
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