Related Experiment Video
Updated: Jul 28, 2026

08:43
Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
The shiverer mouse mutation shi/shi: rescue and preimplantation detection
C Readhead1, A L Muggleton-Harris
1Division of Biology, California Institute of Technology, Pasadena 91125.
Human Reproduction (Oxford, England)
|January 1, 1991
Abstract:
The shiverer mouse mutation has been used as a model in this series of experiments. Germ-line therapy of this disorder has been demonstrated by producing mice transgenic for the wild-type gene for myelin basic protein (MBP). The mutation has also been diagnosed in preimplantation mouse blastocysts.

