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Updated: Jul 18, 2026

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
08:22

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

Infant C677T MTHFR polymorphism and severe mental retardation

Gary M Shaw1, Laura Jelliffe-Pawlowski, Verne Nelson

  • 1California Birth Defects Monitoring Program, Berkeley, California 94710, USA. gsh@cbdmp.org

Birth Defects Research. Part A, Clinical and Molecular Teratology
|December 7, 2006
PubMed
Summary

Infants with the MTHFR gene TT genotype showed no increased risk of severe mental retardation overall. However, Hispanic children with TT or CT genotypes had a higher risk, suggesting a potential link to folate metabolism.

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