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Updated: Jul 18, 2026

Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
An attempt to understand the paradox of anorexia nervosa without drive for thinness
Giovanni Abbate-Daga1, Andrea Pierò, Carla Gramaglia
1Department of Neurosciences, Section of Psychiatry, University of Turin, Turin, Italy.
Abstract:
The "atypical" subgroup of women with anorexia nervosa not characterized by drive for thinness (DT) was studied. The study group comprised 151 anorectic patients (restrictor anorectics [AN-R], n=74; binge-purging anorectics [AN-BP], n=77). Subjects completed the following self-administered questionnaires: Eating Disorder Inventory-2 (EDI-2), Temperament and Character Inventory (TCI), State-Trait Anger Expression Inventory (STAXI), and Beck Depression Inventory (BDI). Patients were subdivided into three groups on the basis of body mass index (BMI) and DT score: AN-I with a BMI<15 and DT<7 (n=24); AN-II with a BMI>15 and DT<7 (n=34); and AN-III with a BMI<17.5 and DT>7 (n=93). Patients belonging to the AN-III group had a more severe disorder and form of psychopathology based on their scores on several scales. No association emerged between personality disorders and any single subgroup. Three hypotheses emerge: (1) some patients (about 38%) deny DT and provide negative answers on the questionnaires; (2) patients without DT (even when malnourished) seem to show less severe psychopathologic and personality traits; and (3) patients without DT answer questions honestly, but they have developed a character structure that enables them to feel negative and ego-dystonic emotions regarding their condition. Implications for treatment are discussed.
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