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Compact, high performance surface plasmon resonance imaging system.

Timothy M Chinowsky1, Michael S Grow, Kyle S Johnston

  • 1timchinowsky@alum.mit.edu

Biosensors & Bioelectronics
|December 8, 2006
PubMed
Summary
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We developed a compact surface plasmon resonance imaging instrument for biomolecular detection. This high-performance device offers real-time analysis and broad applicability in various research fields.

Area of Science:

  • Biophotonics
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Surface plasmon resonance (SPR) imaging is a powerful technique for studying biomolecular interactions.
  • Existing SPR instruments can be bulky and complex, limiting their field applicability.
  • There is a need for compact, high-performance SPR imaging systems for diverse applications.

Purpose of the Study:

  • To report the construction and characterization of a novel, compact SPR imaging instrument.
  • To demonstrate the instrument's capability for real-time detection and quantification of biomolecular binding events.
  • To showcase the device's potential for various applications requiring high-resolution imaging of spatial structures.

Main Methods:

  • Designed a compact SPR imager utilizing a folded light path, wide-field optics, and a tilted detector.

Related Experiment Videos

  • Incorporated a bright diode light source and a fast-frame-rate detector with integrated digital signal processing for real-time image averaging.
  • Employed microfluidic flowcells for simultaneous analysis of multiple sample streams.

    • Main Results:

    • Achieved a high-performance optical system within a small form factor (7 in. x 4 in. x 2 in.).
    • Demonstrated improved signal-to-noise ratio through real-time averaging of multiple images.
    • Quantified refractive index measurement noise levels, reaching approximately 5 x 10(-7) refractive index units root-mean-square.
    • Successfully performed competition assays for an antiepileptic drug, phenytoin.

    Conclusions:

    • The developed SPR imager is simple, compact, and offers high performance.
    • Its design facilitates ready application across a wide range of research and diagnostic fields.
    • The instrument enables versatile detection, quantification, and visualization of spatially structured biomolecular binding events.