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Seizures during treatment of Vitamin B12 deficiency

G Benbir1, S Uysal, S Saltik

  • 1Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Seizure
|December 8, 2006
PubMed

Insights

Vitamin B12 deficiency can cause infantile seizures, sometimes worsening after treatment begins. Prompt antiepileptic and Vitamin B12 therapy resolved seizures and normalized brain activity in infants.

Area of Science:

  • Pediatrics
  • Neurology
  • Nutritional Science

Background:

  • Infantile seizures present diversely; etiology impacts prognosis.
  • Vitamin B12 deficiency is a rare, benign cause of infantile seizures.
  • Symptoms include anemia, developmental delay, and neurological issues.

Observation:

  • Three infants with Vitamin B12 deficiency and developmental delay experienced prolonged seizures post-treatment.
  • Seizures were focal/multifocal and emerged after intramuscular Vitamin B12 initiation.
  • This contrasts with reported cases of involuntary movements appearing after supplementation.

Findings:

  • Concurrent Vitamin B12 and antiepileptic treatment resolved seizures.
  • Electroencephalographic normalization occurred within months.
  • No seizure relapses were observed during follow-up.

Implications:

  • Highlights a rare, paradoxical reaction of seizures to Vitamin B12 treatment in infants.
  • Emphasizes the need for vigilant monitoring during Vitamin B12 therapy in infants with seizures.
  • Suggests a potential link between Vitamin B12 metabolism and seizure activity in infants.

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