Related Experiment Video
Updated: Jul 18, 2026

Electrochemotherapy of Tumours
Published on: December 15, 2008
Electrochemotherapy of Mycosis fungoides by interferon-alpha
E Peycheva1, I Daskalov, I Tsoneva
1National Centre of Oncology, Clinic of Oncodermatology, 6 Plovdivsko pole Blv., 1756 Sofia, Bulgaria.
Abstract:
Eight patients with 29 lesions of histologically verified 1st stage of Mycosis fungoides were successfully treated by electrochemotherapy with interferon-alpha. For this purpose 8 biphasic pulses were used, each of 50+50 micros duration with 900 micros interpulse intervals, resulting in a burst of 7.1 ms total duration. Compared to the traditional monoimmunotherapy with interferon-alpha applied three times weekly for a total of 4 weeks, the electrochemotherapy was very efficient. Complete response (CR) was observed in 25 (86%) of the 29 treated lesions by single-act electrochemotherapy with interferon-alpha. At the end of the 12-month period, all 29 lesions showed 100% complete response (CR). New lesions for a period of 12 months were not observed. The expected mechanism involved in multiple cytotoxic action of interferon-alpha could be the local increased concentration in the tumour and prolongation of the time of its action after the application of pulses.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Antifungal Agents
Tumor Immunotherapy
