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PharmGED: Pharmacogenetic Effect Database.

C J Zheng1, L Y Han, B Xie

  • 1Department of Pharmacy, Bioinformatics and Drug Design Group, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, Singapore 117543.

Nucleic Acids Research
|December 8, 2006
PubMed
Summary
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A new database, Pharmacogenetic Effect Database (PharmGED), consolidates pharmacogenetic information. This resource aids personalized medicine by providing quick access to drug response variations and genetic polymorphisms.

Area of Science:

  • Pharmacogenomics
  • Bioinformatics
  • Drug Discovery

Background:

  • Personalized medicine development requires understanding pharmacogenetic effects and drug-response variations.
  • Existing pharmacogenetic data is often fragmented across separate web pages and lengthy literature excerpts.
  • A centralized, easily accessible database is needed to streamline the assessment of pharmacogenetic information.

Purpose of the Study:

  • To develop a comprehensive database, Pharmacogenetic Effect Database (PharmGED), for consolidating pharmacogenetic information.
  • To provide a centralized resource for sequence, function, polymorphism, affected drugs, and pharmacogenetic effects.
  • To facilitate the rapid assessment of pharmacogenetic data for research and development.

Main Methods:

  • Development of the Pharmacogenetic Effect Database (PharmGED).

Related Experiment Videos

  • Integration of data on genetic sequences, protein functions, polymorphisms, and drug interactions.
  • Curation of information from scientific literature.

    • Main Results:

    • PharmGED provides integrated data on pharmacogenetic effects, including sequence, function, and polymorphism information.
    • The database contains 1825 entries, covering 108 diseases, 266 proteins, 693 polymorphisms, and 414 drugs/ligands.
    • Data is sourced from 856 references and is accessible online at http://bidd.cz3.nus.edu.sg/phg/.

    Conclusions:

    • PharmGED serves as a valuable, centralized resource for pharmacogenetic research.
    • The database facilitates the development of personalized medicines by simplifying access to critical drug-response data.
    • Easy and quick assessment of pharmacogenetic information is now possible through PharmGED.