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PIDD: database for Protein Inter-atomic Distance Distributions.

Di Wu1, Feng Cui, Robert Jernigan

  • 1Program on Bioinformatics and Computational Biology, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

Nucleic Acids Research
|December 8, 2006
PubMed
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Protein Inter-atomic Distance Distributions (PIDD) is a database for protein modeling. It analyzes inter-atomic distances from known structures to aid in protein structure determination and refinement.

Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Biophysics

Background:

  • Protein structure determination is crucial for understanding biological function.
  • Existing methods for protein modeling often rely on geometric constraints.
  • Statistical analysis of inter-atomic distances can provide valuable insights into protein structure.

Purpose of the Study:

  • To introduce the Protein Inter-atomic Distance Distributions (PIDD) database and system.
  • To provide a resource for analyzing protein inter-atomic distance distributions.
  • To facilitate distance-based protein modeling and structure refinement.

Main Methods:

  • Collected and analyzed statistical data of protein inter-atomic distances from the Protein Data Bank (PDB).
  • Developed a system for generating, caching, and displaying these distance distributions.

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  • Implemented a web interface for user-friendly access and data retrieval.
  • Main Results:

    • The PIDD database hosts comprehensive statistical distributions of protein inter-atomic distances.
    • The system can generate, cache, and visualize these distributions for various distance types and ranges.
    • The collected data can be used to extract geometric restraints and mean-force potentials.

    Conclusions:

    • PIDD serves as a valuable resource for distance-based protein modeling.
    • The database supports protein structure determination, including NMR and comparative modeling.
    • PIDD offers a user-friendly platform for accessing and utilizing protein inter-atomic distance data.