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Mouse Phenome Database (MPD).

Molly A Bogue1, Stephen C Grubb, Terry P Maddatu

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. molly.bogue@jax.org

Nucleic Acids Research
|December 8, 2006
PubMed
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The Mouse Phenome Database (MPD) centralizes mouse strain data for researchers. This resource aids in selecting appropriate mouse models for physiological studies, drug testing, and disease research.

Area of Science:

  • Genetics
  • Bioinformatics
  • Animal Models

Background:

  • The laboratory mouse is a key genetic model for human biology and pathology research.
  • Access to comprehensive phenotypic and genotypic data is crucial for effective research.
  • Existing data repositories may lack centralization or comprehensive strain information.

Purpose of the Study:

  • To establish a centralized repository for mouse phenotypic and genotypic data.
  • To facilitate the selection of appropriate mouse strains for diverse research applications.
  • To provide a platform for data analysis and in silico hypothesis testing.

Main Methods:

  • Data aggregation from the scientific community regarding inbred mouse strains.
  • Development of an electronic, centralized database for strain characteristics.

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  • Implementation of tools for data analysis and in silico hypothesis testing.

    • Main Results:

    • The Mouse Phenome Database (MPD) provides a comprehensive collection of phenotypic and genotypic data for numerous mouse strains.
    • MPD enables researchers to electronically access and analyze strain data.
    • The database supports informed strain selection for physiological studies, toxicology, and disease modeling.

    Conclusions:

    • MPD serves as a vital community resource for biomedical researchers.
    • Centralized mouse strain data enhances the efficiency and effectiveness of research.
    • MPD facilitates the identification and functional analysis of genes in normal and disease pathways.