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Updated: Jul 18, 2026
08:46
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Telomere dysfunction drives increased mutation by error-prone polymerases Rev1 and zeta in Saccharomyces cerevisiae
1Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010-0269, USA.
Genetics
|December 8, 2006
Abstract:
Using a model system, we have shown that replicative senescence is accompanied by a 16-fold increase in base substitution and frameshift mutations near a chromosome end. The increase was dependent on error-prone polymerases required for the mutagenic response to DNA lesions that block the replication fork.
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