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Effectiveness of tolterodine in nonneurogenic voiding dysfunction

Ramesh Babu1

  • 1Pediatric Urology Unit, Sri Ramachandra Medical College and Research Institute, Chennai, India. kidsdocs@sancharnet.in

Indian Pediatrics
|December 8, 2006
PubMed

Insights

Long-acting tolterodine effectively treats non-neurogenic voiding dysfunction in children. This medication showed significant symptom improvement and high compliance with a once-daily dosage.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Non-neurogenic voiding dysfunction (NNVD) is a common condition in children.
  • Current treatment options for NNVD may have limitations in efficacy and compliance.

Purpose of the Study:

  • To evaluate the efficacy and safety of long-acting tolterodine in pediatric patients with NNVD.
  • To assess the impact of tolterodine on the dysfunctional voiding symptom score (DVSS).

Main Methods:

  • A study involving 44 children diagnosed with NNVD.
  • Patients received either 2mg or 4mg of long-acting tolterodine tartrate once daily.
  • The Dysfunctional Voiding Symptom Score (DVSS) was used to measure symptom severity before and after treatment.

Main Results:

  • A significant reduction in mean DVSS was observed post-treatment (P < 0.01).
  • Symptomatic cure was achieved in 63.6% of patients, with improvement in 31.8%.
  • High compliance (95%) and a favorable side effect profile were noted with the once-daily dosing regimen.

Conclusions:

  • Long-acting tolterodine is an effective treatment for children with non-neurogenic voiding dysfunction.
  • The once-daily formulation offers good compliance and a minimal side effect profile in pediatric patients.
  • Tolterodine demonstrates a significant positive impact on voiding symptoms in children.

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