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Effectiveness of tolterodine in nonneurogenic voiding dysfunction
1Pediatric Urology Unit, Sri Ramachandra Medical College and Research Institute, Chennai, India. kidsdocs@sancharnet.in
Indian Pediatrics
|December 8, 2006
Summary
Long-acting tolterodine effectively treats non-neurogenic voiding dysfunction in children. This medication showed significant symptom improvement and high compliance with a once-daily dosage.
Area of Science:
- Pediatric Urology
- Pharmacology
- Clinical Medicine
Background:
- Non-neurogenic voiding dysfunction (NNVD) is a common condition in children.
- Current treatment options for NNVD may have limitations in efficacy and compliance.
Purpose of the Study:
- To evaluate the efficacy and safety of long-acting tolterodine in pediatric patients with NNVD.
- To assess the impact of tolterodine on the dysfunctional voiding symptom score (DVSS).
Main Methods:
- A study involving 44 children diagnosed with NNVD.
- Patients received either 2mg or 4mg of long-acting tolterodine tartrate once daily.
- The Dysfunctional Voiding Symptom Score (DVSS) was used to measure symptom severity before and after treatment.
Main Results:
- A significant reduction in mean DVSS was observed post-treatment (P < 0.01).
- Symptomatic cure was achieved in 63.6% of patients, with improvement in 31.8%.
- High compliance (95%) and a favorable side effect profile were noted with the once-daily dosing regimen.
Conclusions:
- Long-acting tolterodine is an effective treatment for children with non-neurogenic voiding dysfunction.
- The once-daily formulation offers good compliance and a minimal side effect profile in pediatric patients.
- Tolterodine demonstrates a significant positive impact on voiding symptoms in children.
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