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Acute renal failure related to infectious disease in infancy and childhood
A S Gokalp1, A Oguz, A Gultekin
1Department of Paediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Insights
Infectious diseases, particularly sepsis, were the primary cause of acute renal failure in 94% of children studied in Turkey. Many of these infections are preventable, highlighting a critical public health concern.
Area of Science:
- Pediatrics
- Nephrology
- Infectious Diseases
Background:
- Acute renal failure (ARF) in children poses significant health challenges.
- Identifying the underlying causes of ARF is crucial for effective prevention and treatment.
- Infectious etiologies are a major concern in pediatric ARF, especially in resource-limited settings.
Purpose of the Study:
- To investigate the prevalence and causes of acute renal failure in children in Sivas, Turkey.
- To identify the specific infectious agents and conditions leading to ARF in this pediatric population.
- To assess the role of preventable infectious diseases in the etiology of pediatric ARF.
Main Methods:
- A prospective study was conducted between 1983 and 1989.
- The study included 109 children diagnosed with acute renal failure.
- Data on the underlying causes, with a focus on infectious diseases, were collected and analyzed.
Main Results:
- Out of 109 children with ARF, 94 (86.2%) had an infectious disease as the underlying cause.
- Preventable infections such as acute gastro-enteritis, sepsis, and post-streptococcal acute glomerulonephritis were frequently identified.
- Sepsis emerged as the infectious condition with the highest incidence rate among the ARF cases.
Conclusions:
- Infectious diseases are a predominant cause of acute renal failure in children in the studied region of Turkey.
- A significant proportion of pediatric ARF cases are linked to preventable infectious conditions.
- Targeted interventions addressing sepsis and other common infections are essential for reducing the burden of pediatric ARF.
Abstract:
In this prospective study done between 1983 and 1989, of 109 children with acute renal failure in Sivas, Turkey, infectious disease was found in 94. This was related mainly to preventable disease such as acute gastro-enteritis, sepsis and post-streptococcal acute glomerulonephritis. Within this infectious disease group, the highest incidence rate was found in sepsis.